The COVID-19 pandemic is viewed by many as the biggest global crisis since WWII and had profound effects on the daily lives of people and decision-making worldwide. Using the pandemic as a system-wide agenda shock, we employ a difference-in-differences design to estimate its causal effects on inequalities in political access, and social media prominence among business interests and NGOs. Our argument is twofold. First, the urgency and uncertainty of crises incentivized decision-makers to privilege providing access to business groups over securing inclusivity in the types of interests consulted. Second, NGOs compensated by increasing prominence in public communications. Our analysis of data from over 10,000 interest groups from over 100 countries registered in the European Union supports these hypotheses. Business interests successfully capitalized on the crisis in insider access, while NGOs increased prominence on social media. The results have wider implications for understanding how large-scale crises affect inequalities in representation.